Title : Fas-associated factor 1, FAF1, is a member of Fas death-inducing signaling complex.

Pub. Date : 2003 Jun 27

PMID : 12702723






2 Functional Relationships(s)
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Protein Name
Organism
1 FADD and caspase-8 colocalized with Fas in Jurkat cells validating the presence of FAF1 in the authentic Fas-DISC. ammonium ferrous sulfate caspase 8 Homo sapiens
2 In addition, the FAF1 deletion mutant lacking the N terminus where Fas, FADD, and caspase-8 interact protected Jurkat cells from Fas-induced apoptosis demonstrating dominant-negative phenotype. ammonium ferrous sulfate caspase 8 Homo sapiens