Title : Dysregulatory dysequilibrium of gene transcription and of nuclear transport in polyglutamine neuro-degeneration.

Pub. Date : 2003 Jun

PMID : 12699716






1 Functional Relationships(s)
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1 Within such a scheme of progressive expansion of polyglutamine stretches in strict parallel correlation with increased CAG trinucleotide repeats in genes such as ataxin-7 and its messenger RNA, it would appear that a fundamental relationship of accumulation directly inducing biophysical disruption between nuclear/nucleolar and cytoplasmic protein machineries would constitute a dysfunctional dysequilibrium accounting for self-progressive neuronal degeneration with atrophy of the cerebral cortex and ganglia such as the caudate, that is limited often to specific population groups of neurons. polyglutamine ataxin 7 Homo sapiens