Title : Autocrine down-regulation of glucocorticoid receptors by interleukin-11 in human osteoblast-like cell lines.

Pub. Date : 2003 Apr

PMID : 12697042






1 Functional Relationships(s)
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1 Similar to IL-6, both constitutive and IL-1beta-inducible IL-11 release were dose-dependently inhibited by cortisol (P<0.01); at variance with IL-6, exogenous IL-11 dose-dependently decreased GR numbers in MG-63 cells (P<0.05), while anti-IL-11 antibody significantly increased GR numbers in both cell lines (P<0.05). Hydrocortisone interleukin 6 Homo sapiens