Pub. Date : 2003 May
PMID : 12695338
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Additionally, phenobarbital (PB)-inducible Oatp2 and Mrp3 gene expression was significantly increased in the PXR-KO mice when compared with wild-type PB-treated mice. | Phenobarbital | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 2 | Additionally, phenobarbital (PB)-inducible Oatp2 and Mrp3 gene expression was significantly increased in the PXR-KO mice when compared with wild-type PB-treated mice. | Phenobarbital | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 3 | Additionally, phenobarbital (PB)-inducible Oatp2 and Mrp3 gene expression was significantly increased in the PXR-KO mice when compared with wild-type PB-treated mice. | Phenobarbital | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 4 | We also examined the effect of PXR ablation on PB-inducible hepatic CYP3A activity in vivo. | Phenobarbital | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 5 | Microsomes isolated from PB-treated PXR-KO mice exhibited a significantly elevated rate of testosterone 6 beta-hydroxylation when compared with microsomes isolated from wild-type PB-treated mice. | Phenobarbital | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |
| 6 | PB treatment produced significantly increased levels of hepatomegaly in PXR-KO mice when compared with wild-type PB-treated mice. | Phenobarbital | nuclear receptor subfamily 1, group I, member 2 | Mus musculus |