Title : Down-regulation of Raf-1 kinase is associated with paclitaxel resistance in human breast cancer MCF-7/Adr cells.

Pub. Date : 2003 Apr 10

PMID : 12691824






3 Functional Relationships(s)
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1 In addition, paclitaxel greatly increased c-Jun N-terminal protein kinase (JNK) activity whereas showing a small enhancing effect on extracellular-regulated kinases (ERK) activity. Paclitaxel mitogen-activated protein kinase 8 Homo sapiens
2 In addition, paclitaxel greatly increased c-Jun N-terminal protein kinase (JNK) activity whereas showing a small enhancing effect on extracellular-regulated kinases (ERK) activity. Paclitaxel mitogen-activated protein kinase 8 Homo sapiens
3 Thus, the findings suggest that paclitaxel-induced apoptosis is mediated by JNK and occurs in parallel with suppression of the Raf-1 kinase activity in parental MCF-7 cells. Paclitaxel mitogen-activated protein kinase 8 Homo sapiens