Pub. Date : 2003 Aug 15
PMID : 12689930
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | PlGF-mediated cytochemokine mRNA and protein expression was inhibited by PD98059 and wortmannin, inhibitors of mitogen-activated protein kinase kinase (MAPK/MEK) kinase and phosphatidylinositol-3 (PI3) kinase, respectively, but not by SB203580, a p38 kinase inhibitor. | Wortmannin | mitogen-activated protein kinase 3 | Homo sapiens |
| 2 | PlGF caused a time-dependent transient increase in phosphorylation of extracellular signal-regulated kinase-1/2 (ERK-1/2), which was completely inhibited by wortmannin, indicating that activation of PI3 kinase preceded MEK activation. | Wortmannin | mitogen-activated protein kinase 3 | Homo sapiens |
| 3 | PlGF caused a time-dependent transient increase in phosphorylation of extracellular signal-regulated kinase-1/2 (ERK-1/2), which was completely inhibited by wortmannin, indicating that activation of PI3 kinase preceded MEK activation. | Wortmannin | mitogen-activated protein kinase 3 | Homo sapiens |