Title : Ketotifen reverses MDR1-mediated multidrug resistance in human breast cancer cells in vitro and alleviates cardiotoxicity induced by doxorubicin in vivo.

Pub. Date : 2003 May

PMID : 12687290






1 Functional Relationships(s)
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1 RESULTS: Ketotifen was found to restore the sensitivity of P-glycoprotein-overexpressing multidrug-resistant MCF-7/adr cells to doxorubicin, mitoxantrone, VP-16 and vinblastine, but not to methotrexate or camptothecin. Vinblastine ATP binding cassette subfamily B member 1 Homo sapiens