Title : Endothelin ET A- and ET B-receptor-mediated inhibition of noradrenaline release from isolated rat stomach.

Pub. Date : 2003 Jan

PMID : 12686728






2 Functional Relationships(s)
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1 The inhibitory effect of endothelin-1 (3 x 10(-)(9) M) on noradrenaline release was abolished by BQ-123 (a selective antagonist of endothelin ET(A) receptors) in a dose-dependent manner (10(-)(7) and 10(-)(6) M), but not influenced by BQ-788 (a selective antagonist of endothelin ET(B) receptors) (10(-)(7) and 10(-)(6) M). Norepinephrine endothelin 1 Rattus norvegicus
2 The endothelin-1-induced inhibition of noradrenaline release was attenuated by pretreatment with pertussis toxin (10 micro g/animal, i.v., 4 days before experiments), but not influenced by indomethacin (3 x 10(-)(6) M). Norepinephrine endothelin 1 Rattus norvegicus