Title : Inhibition of human glutathione S-transferase P1-1 by the flavonoid quercetin.

Pub. Date : 2003 May 6

PMID : 12686490






3 Functional Relationships(s)
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1 Inhibition studies with the GSTP1-1 mutants C47S, C101S and the double mutant C47S/C101S showed that cysteine 47 is the key residue in the interaction between quercetin and GSTP1-1. Cysteine glutathione S-transferase pi 1 Homo sapiens
2 Inhibition studies with the GSTP1-1 mutants C47S, C101S and the double mutant C47S/C101S showed that cysteine 47 is the key residue in the interaction between quercetin and GSTP1-1. Cysteine glutathione S-transferase pi 1 Homo sapiens
3 Nevertheless, the results of the present study indicate that quinone-type oxidation products of quercetin likely act as specific active site inhibitors of GSTP1-1 by binding to cysteine 47. Cysteine glutathione S-transferase pi 1 Homo sapiens