Pub. Date : 2003 Jun
PMID : 12684728
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to investigate the contribution of CYP2C9 and CYP2C19 and their polymorphisms to the variability of cyclophosphamide activation. | Cyclophosphamide | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |
| 2 | We found a statistically significant correlation ( r(s)=0.65, P=0.003) between 4-hydroxylation of cyclophosphamide and 5"-hydroxylation of R-omeprazole, a measure of CYP2C19 activity in human liver microsomes ( n=19). | Cyclophosphamide | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |
| 3 | In conclusion, based on the correlation with the formation of R-5"-hydroxyomeprazole, CYP2C19 may partly contribute to the bioactivation of cyclophosphamide in human liver microsomes, while the role of CYP2C9 appears minor. | Cyclophosphamide | cytochrome P450 family 2 subfamily C member 19 | Homo sapiens |