Title : The multidrug resistance protein ABCC1 drug-binding domains show selective sensitivity to mild detergents.

Pub. Date : 2003 Apr 18

PMID : 12684054






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In this study, we describe the use of [125I]iodoaryl azido-rhodamine123 (IAARh123)-a photoactive drug analogue of rhodamine 123, to study the effects of mild detergents and denaturing agents on MRP1-drug binding in membrane vesicles prepared from HeLa cells transfected with the MRP1 cDNA. IAARh123 ATP binding cassette subfamily C member 1 Homo sapiens
2 In this study, we describe the use of [125I]iodoaryl azido-rhodamine123 (IAARh123)-a photoactive drug analogue of rhodamine 123, to study the effects of mild detergents and denaturing agents on MRP1-drug binding in membrane vesicles prepared from HeLa cells transfected with the MRP1 cDNA. IAARh123 ATP binding cassette subfamily C member 1 Homo sapiens
3 Sodium deoxycholate (SDC) and octyl-beta-glucoside (OG), structurally similar to CHAPS and Brij35 and disrupting the lipid bilayer, showed a modest increase of MRP1 photolabeling with IAARh123. IAARh123 ATP binding cassette subfamily C member 1 Homo sapiens