Title : Protein kinase B activation by reactive oxygen species is independent of tyrosine kinase receptor phosphorylation and requires SRC activity.

Pub. Date : 2003 Jun 6

PMID : 12682076






1 Functional Relationships(s)
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1 On the contrary, PP2 (4-amino-5-(4-chlorophenyl)-7-(t-butyl)pyrazole[3,4-d]pyrimidine), an inhibitor of Src kinase, completely prevents DEM- and H2O2-induced AKT activation but has no effect on the pathway of ERKs. Hydrogen Peroxide SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens