Title : KR-31372 inhibits KDR/Flk-1 tyrosine phosphorylation via K+(ATP) channel opening in its antiangiogenic effect.

Pub. Date : 2003 Apr 4

PMID : 12681433






1 Functional Relationships(s)
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Protein Name
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1 KR-31372 (10(-6)-10(-4) M) and levcromakalim (10(-5) M) concentration-dependently suppressed the VEGF(165)-induced increases in KDR/Flk-1 tyrosine phosphorylation as well as the extracellular signal-related kinase 1/2 (ERK1/2), p38 MAK and p125(FAK) tyrosine phosphorylation. Cromakalim protein tyrosine kinase 2 Homo sapiens