Title : P38 mitogen-activated protein kinase mediates hexosamine-induced TGFbeta1 mRNA expression in human mesangial cells.

Pub. Date : 2003 Apr

PMID : 12679868






1 Functional Relationships(s)
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1 The activation of the p38-MAPK was dependent on protein kinase-C. METHODS: The products of the hexosamine biosynthetic pathway were increased by the addition of glucosamine or by the overexpression of the rate-limiting enzyme of the hexosamine pathway, glutamine: fructose-6-phosphate amidotransferase (GFAT). Glucosamine glutamine--fructose-6-phosphate transaminase 1 Homo sapiens