Pub. Date : 2003 Jan 1
PMID : 12679132
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Argatroban (0.1-0.3 mg/kg/h) significantly accelerated thrombolysis by t-PA in both a dose- and time-dependent fashion. | argatroban | plasminogen activator, tissue type | Homo sapiens |
| 2 | Although argatroban (0.1-0.2 mg/kg/h) did not significantly prolong the aPTT and bleeding time (BT) as compared with control, it significantly accelerated thrombolysis by t-PA at these doses of lower bleeding risk. | argatroban | plasminogen activator, tissue type | Homo sapiens |
| 3 | Argatroban (0.3 mg/kg/h) significantly enhanced thrombolysis by t-PA, while UFH (12.5 anti-XaU/kg/h) attenuated it again, despite equivalent prolongation of the aPTT and BT. | argatroban | plasminogen activator, tissue type | Homo sapiens |
| 4 | We conclude that argatroban seems to be a more efficient and safer anticoagulant than UFH for the prevention of thrombus formation and acceleration of t-PA-induced thrombolysis. | argatroban | plasminogen activator, tissue type | Homo sapiens |