Title : The upregulation of type I plasminogen activator inhibitor in oral submucous fibrosis.

Pub. Date : 2003 Jun

PMID : 12676256






3 Functional Relationships(s)
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1 To verify whether arecoline, a major areca nut alkaloid, could affect PAI-1 expression by human BMFs, RT-PCR and Western blots were used. Arecoline serpin family E member 1 Homo sapiens
2 The results demonstrated highly elevated PAI-1 mRNA and protein expression in normal human BMFs stimulated by arecoline. Arecoline serpin family E member 1 Homo sapiens
3 Taken together, these results suggest that PAI-1 expression is significantly upregulated in OSF tissues from areca quid chewers, and arecoline may be responsible for the enhanced PAI-1 expression in vivo. Arecoline serpin family E member 1 Homo sapiens