Title : Potentiation of domperidone-induced catalepsy by a P-glycoprotein inhibitor, cyclosporin A.

Pub. Date : 2003 Apr

PMID : 12673668






2 Functional Relationships(s)
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1 In this study, we aimed to investigate whether cyclosporin A (CsA), a P-gp inhibitor, potentiates EPS induced by DOM. Cyclosporine phosphoglycolate phosphatase Mus musculus
2 These results suggest that CsA increases the brain distribution of DOM by inhibiting P-gp at the BBB, and potentiates catalepsy by increasing the occupancies of the D(1) and D(2) receptors. Cyclosporine phosphoglycolate phosphatase Mus musculus