Pub. Date : 2003 Apr
PMID : 12673034
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we demonstrated the inductive effects of phenobarbital, rifampicin, carbamazepine, phenytoin, prednisolone, ciclosporin and clotrimazole on CYP3A4, CYP3A5 and CYP3A7 mRNA expression, and established the relationship between the expression of human glucocorticoid receptor alpha (hGR) mRNA and the induction of CYP3A4 mRNA in cultured HepG2 cells by reverse transcription polymerase chain reaction (RT-PCR). | Phenobarbital | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In this study, we demonstrated the inductive effects of phenobarbital, rifampicin, carbamazepine, phenytoin, prednisolone, ciclosporin and clotrimazole on CYP3A4, CYP3A5 and CYP3A7 mRNA expression, and established the relationship between the expression of human glucocorticoid receptor alpha (hGR) mRNA and the induction of CYP3A4 mRNA in cultured HepG2 cells by reverse transcription polymerase chain reaction (RT-PCR). | Phenobarbital | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | However, phenytoin and phenobarbital gradually induced CYP3A4 mRNA level by 3 to 4-fold. | Phenobarbital | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |