Title : Overexpression of the stress protein Grp94 reduces cardiomyocyte necrosis due to calcium overload and simulated ischemia.

Pub. Date : 2003 May

PMID : 12670879






2 Functional Relationships(s)
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1 The number of necrotic cells, evaluated by propidium iodide uptake, was reduced when cells from the Grp94-overexpressing H9c2 clone were exposed to conditions simulating ischemia. Propidium heat shock protein 90 beta family member 1 Rattus norvegicus
2 A lower percentage of propidium-iodide positive/GFP-fluorescent myocytes co-expressing exogenous Grp94, with respect to myocytes expressing GFP alone, was observed after exposure to either A23187 (6.6% vs. 14.0%, respectively) or simulated ischemia (8.5% vs. 17.7%, respectively). Propidium heat shock protein 90 beta family member 1 Rattus norvegicus