Title : Design, synthesis and biological activity of beta-carboline-based type-5 phosphodiesterase inhibitors.

Pub. Date : 2003 Apr 17

PMID : 12668004






1 Functional Relationships(s)
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1 The SAR of a series of beta-carboline derived type 5 phosphodiesterase inhibitors has been explored and we have discovered compounds with excellent levels of PDE5 potency and selectivity over PDE6. norharman phosphodiesterase 5A Homo sapiens