Pub. Date : 2003 Apr 8
PMID : 12667067
17 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 2 | Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 3 | Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 4 | Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 5 | Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 6 | Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 7 | Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 8 | Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 9 | Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 10 | Wild-type (WT) apo-CRP is a 47 kDa protease-resistant dimer composed of identical subunits that exhibits a biphasic isotherm in cAMP titration studies. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 11 | The WT CRP-cAMP complex is a protease-sensitive dimer degraded by protease to a dimer core that ranges between 26.5 and 30.5 kDa. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 12 | Differences in the affinity of the position 124 CRP variants for cAMP were observed. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 13 | The binding constants that drive the formation of the WT and L124I CRP-cAMP complexes deviated by not more than a factor of 1.5. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 14 | The data indicate that the van der Waals volume and/or the hyrophobicity of the L124 side chain are important determinants of CRP cAMP binding properties and affect, either directly or indirectly, cAMP-mediated conformation changes in CRP. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 15 | The data indicate that the van der Waals volume and/or the hyrophobicity of the L124 side chain are important determinants of CRP cAMP binding properties and affect, either directly or indirectly, cAMP-mediated conformation changes in CRP. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 16 | The data indicate that the van der Waals volume and/or the hyrophobicity of the L124 side chain are important determinants of CRP cAMP binding properties and affect, either directly or indirectly, cAMP-mediated conformation changes in CRP. | Cyclic AMP | C-reactive protein | Homo sapiens |
| 17 | The data indicate that the van der Waals volume and/or the hyrophobicity of the L124 side chain are important determinants of CRP cAMP binding properties and affect, either directly or indirectly, cAMP-mediated conformation changes in CRP. | Cyclic AMP | C-reactive protein | Homo sapiens |