Title : Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery.

Pub. Date : 2003 Apr 8

PMID : 12667067






17 Functional Relationships(s)
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1 Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. Cyclic AMP C-reactive protein Homo sapiens
2 Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. Cyclic AMP C-reactive protein Homo sapiens
3 Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. Cyclic AMP C-reactive protein Homo sapiens
4 Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. Cyclic AMP C-reactive protein Homo sapiens
5 Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. Cyclic AMP C-reactive protein Homo sapiens
6 Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. Cyclic AMP C-reactive protein Homo sapiens
7 Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. Cyclic AMP C-reactive protein Homo sapiens
8 Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. Cyclic AMP C-reactive protein Homo sapiens
9 Interaction of CRP L124 with cAMP affects CRP cAMP binding constants, cAMP binding cooperativity, and CRP allostery. Cyclic AMP C-reactive protein Homo sapiens
10 Wild-type (WT) apo-CRP is a 47 kDa protease-resistant dimer composed of identical subunits that exhibits a biphasic isotherm in cAMP titration studies. Cyclic AMP C-reactive protein Homo sapiens
11 The WT CRP-cAMP complex is a protease-sensitive dimer degraded by protease to a dimer core that ranges between 26.5 and 30.5 kDa. Cyclic AMP C-reactive protein Homo sapiens
12 Differences in the affinity of the position 124 CRP variants for cAMP were observed. Cyclic AMP C-reactive protein Homo sapiens
13 The binding constants that drive the formation of the WT and L124I CRP-cAMP complexes deviated by not more than a factor of 1.5. Cyclic AMP C-reactive protein Homo sapiens
14 The data indicate that the van der Waals volume and/or the hyrophobicity of the L124 side chain are important determinants of CRP cAMP binding properties and affect, either directly or indirectly, cAMP-mediated conformation changes in CRP. Cyclic AMP C-reactive protein Homo sapiens
15 The data indicate that the van der Waals volume and/or the hyrophobicity of the L124 side chain are important determinants of CRP cAMP binding properties and affect, either directly or indirectly, cAMP-mediated conformation changes in CRP. Cyclic AMP C-reactive protein Homo sapiens
16 The data indicate that the van der Waals volume and/or the hyrophobicity of the L124 side chain are important determinants of CRP cAMP binding properties and affect, either directly or indirectly, cAMP-mediated conformation changes in CRP. Cyclic AMP C-reactive protein Homo sapiens
17 The data indicate that the van der Waals volume and/or the hyrophobicity of the L124 side chain are important determinants of CRP cAMP binding properties and affect, either directly or indirectly, cAMP-mediated conformation changes in CRP. Cyclic AMP C-reactive protein Homo sapiens