Title : Expression of transforming growth factor beta 1 in mesenchymal stem cells: potential utility in molecular tissue engineering for osteochondral repair.

Pub. Date : 2002

PMID : 12658748






3 Functional Relationships(s)
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1 The full-length rat TGF-beta 1 cDNA was transfected to MSCs mediated by lipofectamine and then selected with G418, a synthetic neomycin analog. antibiotic G 418 transforming growth factor, beta 1 Rattus norvegicus
2 The lipofectamine-mediated gene therapy efficiently transfected MSCs in vitro with the TGF-beta 1 gene causing a marked up-regulation in TGF-beta 1 expression as compared with the vector-transfected control groups, and the increased expression persisted for at least 4 weeks after selected with G418. antibiotic G 418 transforming growth factor, beta 1 Rattus norvegicus
3 The lipofectamine-mediated gene therapy efficiently transfected MSCs in vitro with the TGF-beta 1 gene causing a marked up-regulation in TGF-beta 1 expression as compared with the vector-transfected control groups, and the increased expression persisted for at least 4 weeks after selected with G418. antibiotic G 418 transforming growth factor, beta 1 Rattus norvegicus