Title : Synthesis of novel thrombin inhibitors. Use of ring-closing metathesis reactions for synthesis of P2 cyclopentene- and cyclohexenedicarboxylic acid derivatives.

Pub. Date : 2003 Mar 27

PMID : 12646027






1 Functional Relationships(s)
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1 The thrombin inhibitory tripeptide d-Phe-Pro-Arg has been mimicked using either cyclopentenedicarboxylic derivatives or a cyclohexenedicarboxylic derivative as surrogate for the P2 proline. Proline coagulation factor II, thrombin Homo sapiens