Title : c-Src-dependent tyrosine phosphorylation of IKKbeta is involved in tumor necrosis factor-alpha-induced intercellular adhesion molecule-1 expression.

Pub. Date : 2003 Mar 14

PMID : 12645577






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ICAM-1 promoter activity was inhibited by a protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or an Src-specific tyrosine kinase inhibitor (PP2). Tetradecanoylphorbol Acetate intercellular adhesion molecule 1 Homo sapiens
2 TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ICAM-1 promoter activity was inhibited by a protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or an Src-specific tyrosine kinase inhibitor (PP2). Tetradecanoylphorbol Acetate intercellular adhesion molecule 1 Homo sapiens
3 Furthermore, the dominant-negative c-Src (KM) mutant inhibited induction of ICAM-1 promoter activity by TNF-alpha or TPA. Tetradecanoylphorbol Acetate intercellular adhesion molecule 1 Homo sapiens
4 Substitution of these residues with phenylalanines abolished ICAM-1 promoter activity and c-Src-dependent phosphorylation of IKKbeta induced by TNF-alpha or TPA. Tetradecanoylphorbol Acetate intercellular adhesion molecule 1 Homo sapiens