Pub. Date : 2003 Mar 14
PMID : 12645577
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ICAM-1 promoter activity was inhibited by a protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or an Src-specific tyrosine kinase inhibitor (PP2). | Tetradecanoylphorbol Acetate | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 2 | TNF-alpha- or 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced ICAM-1 promoter activity was inhibited by a protein kinase C (PKC) inhibitor (staurosporine), tyrosine kinase inhibitors (genistein and herbimycin A), or an Src-specific tyrosine kinase inhibitor (PP2). | Tetradecanoylphorbol Acetate | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 3 | c-Src and Lyn, two members of the Src kinase family, were abundantly expressed in A549 cells, and their activation by TNF-alpha or TPA was inhibited by the same inhibitors. | Tetradecanoylphorbol Acetate | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 4 | c-Src and Lyn, two members of the Src kinase family, were abundantly expressed in A549 cells, and their activation by TNF-alpha or TPA was inhibited by the same inhibitors. | Tetradecanoylphorbol Acetate | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 5 | Furthermore, the dominant-negative c-Src (KM) mutant inhibited induction of ICAM-1 promoter activity by TNF-alpha or TPA. | Tetradecanoylphorbol Acetate | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |
| 6 | Substitution of these residues with phenylalanines abolished ICAM-1 promoter activity and c-Src-dependent phosphorylation of IKKbeta induced by TNF-alpha or TPA. | Tetradecanoylphorbol Acetate | SRC proto-oncogene, non-receptor tyrosine kinase | Homo sapiens |