Title : Par-4 transcriptionally regulates Bcl-2 through a WT1-binding site on the bcl-2 promoter.

Pub. Date : 2003 May 30

PMID : 12644474






4 Functional Relationships(s)
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1 We observed growth arrest and apoptosis, upon decreasing Bcl-2 protein and transcript in the high Bcl-2-expressing, androgen-independent prostate cancer cell line, by all-trans-retinoic acid treatment (ATRA), but this did not occur in the androgen-dependent cell line expressing low levels of Bcl-2. Tretinoin BCL2 apoptosis regulator Homo sapiens
2 We observed growth arrest and apoptosis, upon decreasing Bcl-2 protein and transcript in the high Bcl-2-expressing, androgen-independent prostate cancer cell line, by all-trans-retinoic acid treatment (ATRA), but this did not occur in the androgen-dependent cell line expressing low levels of Bcl-2. Tretinoin BCL2 apoptosis regulator Homo sapiens
3 We observed growth arrest and apoptosis, upon decreasing Bcl-2 protein and transcript in the high Bcl-2-expressing, androgen-independent prostate cancer cell line, by all-trans-retinoic acid treatment (ATRA), but this did not occur in the androgen-dependent cell line expressing low levels of Bcl-2. Tretinoin BCL2 apoptosis regulator Homo sapiens
4 In stable clones expressing ectopic Par-4 and in ATRA-treated cells, we observed decreased Bcl-2 protein and transcript. Tretinoin BCL2 apoptosis regulator Homo sapiens