Pub. Date : 2003 May
PMID : 12639716
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study we show that treatment of intact mouse islets and RINm5F cells with protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) or protein kinase A (PKA) activator forskolin promoted insulin secretion with no changes of [Ca(2+)](i). | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 2 | In the present study we show that treatment of intact mouse islets and RINm5F cells with protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA) or protein kinase A (PKA) activator forskolin promoted insulin secretion with no changes of [Ca(2+)](i). | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 3 | PMA treatment caused translocation of PKC-alpha and PKC- epsilon from cytosol to membrane, implying that selectively PKC-alpha and PKC- epsilon isoforms might be important for insulin secretion. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |
| 4 | PMA treatment caused translocation of PKC-alpha and PKC- epsilon from cytosol to membrane, implying that selectively PKC-alpha and PKC- epsilon isoforms might be important for insulin secretion. | Tetradecanoylphorbol Acetate | protein kinase C, alpha | Rattus norvegicus |