Title : Intracellular metal ion chelators inhibit TNFalpha-induced SP-1 activation and adhesion molecule expression in human aortic endothelial cells.

Pub. Date : 2003 Mar 15

PMID : 12633744






2 Functional Relationships(s)
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1 Treatment of HAEC with DFO (0.01-0.1 mM) or NC (0.1 and 0.5 mM) time- and dose-dependently inhibited TNFalpha-induced protein expression of E-selectin, vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1). Deferoxamine intercellular adhesion molecule 1 Homo sapiens
2 Treatment of HAEC with DFO (0.01-0.1 mM) or NC (0.1 and 0.5 mM) time- and dose-dependently inhibited TNFalpha-induced protein expression of E-selectin, vascular cell adhesion molecule-1 (VCAM-1), and intercellular adhesion molecule-1 (ICAM-1). Deferoxamine intercellular adhesion molecule 1 Homo sapiens