Title : The soluble ectodomain of RetC634Y inhibits both the wild-type and the constitutively active Ret.

Pub. Date : 2003 Jun 15

PMID : 12630912






3 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Substitution of Cys-634 in the extracellular domain of the Ret tyrosine kinase receptor causes its dimerization and activation of its transforming potential. Cysteine ret proto-oncogene Homo sapiens
2 To gain further insight into the molecular basis leading to Ret activation we purified a mutant protein consisting of the entire ectodomain of the Ret carrying a Cys-634-->Tyr substitution (EC-Ret(C634Y)). Cysteine ret proto-oncogene Homo sapiens
3 To gain further insight into the molecular basis leading to Ret activation we purified a mutant protein consisting of the entire ectodomain of the Ret carrying a Cys-634-->Tyr substitution (EC-Ret(C634Y)). Cysteine ret proto-oncogene Homo sapiens