Title : [Enhancement by FK506 of triptolide-induced inhibition of expression of COX-2 and iNOS in human rheumatoid arthritis synovial fibroblasts].

Pub. Date : 2003 Mar

PMID : 12621554






2 Functional Relationships(s)
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1 NF-kappa B activity in TNF alpha-stimulated synovial cells was suppressed more profoundly by FK506 plus TP (10 microg/L) treatment than those with TP (10 microg/L) alone. Tacrolimus nuclear factor kappa B subunit 1 Homo sapiens
2 In conclusion, FK506 enhanced TP-mediated down-regulation of COX-2, iNOS and their inducing products PGE2, NO in human RASF by suppressing the activity of NF-kappa B. Tacrolimus nuclear factor kappa B subunit 1 Homo sapiens