Pub. Date : 2003 Mar
PMID : 12621385
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Disposition and miotic effects of oral alfentanil: a potential noninvasive probe for first-pass cytochrome P4503A activity. | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | BACKGROUND AND OBJECTIVES: Systemic clearance of the opioid alfentanil after intravenous administration is an excellent in vivo probe for hepatic cytochrome P4503A (CYP3A) activity and drug interactions. | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 3 | BACKGROUND AND OBJECTIVES: Systemic clearance of the opioid alfentanil after intravenous administration is an excellent in vivo probe for hepatic cytochrome P4503A (CYP3A) activity and drug interactions. | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 4 | Alfentanil effect (miosis) is a surrogate for plasma alfentanil concentrations, and alfentanil effect kinetics may be a suitable noninvasive probe for hepatic CYP3A. | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 5 | Oral alfentanil might be a probe for first-pass CYP3A activity; however, it is not used clinically, and oral alfentanil disposition is unknown. | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 6 | Oral alfentanil may be a suitable probe for first-pass CYP3A activity. | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 7 | Further studies are warranted to determine whether oral alfentanil and alfentanil effect kinetics may be a suitable noninvasive in vivo probe for first-pass CYP3A activity. | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 8 | Further studies are warranted to determine whether oral alfentanil and alfentanil effect kinetics may be a suitable noninvasive in vivo probe for first-pass CYP3A activity. | Alfentanil | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |