Title : The native-like conformation of Ure2p in fibrils assembled under physiologically relevant conditions switches to an amyloid-like conformation upon heat-treatment of the fibrils.

Pub. Date : 2003 Feb

PMID : 12615539






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 It is believed that assembly of intact Ure2p into fibrillar polymers that bind Congo Red and show yellow-green birefringence upon staining and are resistant to proteolysis is the consequence of a major change in the conformation of the protein. Congo Red glutathione peroxidase Saccharomyces cerevisiae S288C
2 We recently dissected the assembly process of Ure2p and showed the protein to retain its native alpha-helical structure upon assembly into protein fibrils that are similar to amyloids in that they are straight, bind Congo red and show green-yellow birefringence and have an increased resistance to proteolysis (). Congo Red glutathione peroxidase Saccharomyces cerevisiae S288C