Title : Molecular mechanism of nuclear translocation of an orphan nuclear receptor, SXR.

Pub. Date : 2003 Mar

PMID : 12606758






3 Functional Relationships(s)
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1 We observed that pregnane X receptor (PXR), the mouse ortholog of SXR, was retained in the cytoplasm of hepatic cells of untreated mice, whereas PXR was translocated to the nucleus after administration of a ligand, pregnenolone 16 alpha-carbonitrile. Pregnenolone nuclear receptor subfamily 1, group I, member 2 Mus musculus
2 We observed that pregnane X receptor (PXR), the mouse ortholog of SXR, was retained in the cytoplasm of hepatic cells of untreated mice, whereas PXR was translocated to the nucleus after administration of a ligand, pregnenolone 16 alpha-carbonitrile. Pregnenolone nuclear receptor subfamily 1, group I, member 2 Mus musculus
3 We observed that pregnane X receptor (PXR), the mouse ortholog of SXR, was retained in the cytoplasm of hepatic cells of untreated mice, whereas PXR was translocated to the nucleus after administration of a ligand, pregnenolone 16 alpha-carbonitrile. Pregnenolone nuclear receptor subfamily 1, group I, member 2 Mus musculus