Title : Nitric oxide donors inhibit formation of the Apaf-1/caspase-9 apoptosome and activation of caspases.

Pub. Date : 2003 May 1

PMID : 12605597






1 Functional Relationships(s)
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1 Indeed, using Jurkat cells as a model system, we demonstrate that NO donors block Fas- and etoposide-induced caspase activation and apoptosis (downstream of mitochondrial membrane depolarization) and cytochrome c release. Etoposide cytochrome c, somatic Homo sapiens