Title : von Hippel-Lindau protein binds hyperphosphorylated large subunit of RNA polymerase II through a proline hydroxylation motif and targets it for ubiquitination.

Pub. Date : 2003 Mar 4

PMID : 12604794






1 Functional Relationships(s)
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1 In agreement with the computational model, we show biochemical evidence that pVHL specifically binds the hyperphosphorylated Rpb1 in a proline-hydroxylation-dependent manner, targeting it for ubiquitination. Proline von Hippel-Lindau tumor suppressor Homo sapiens