Title : The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif.

Pub. Date : 2003 May 2

PMID : 12604610






1 Functional Relationships(s)
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1 A point mutation of the TOS motif also eliminates all in vitro mTOR-catalyzed 4E-BP1 phosphorylation and abolishes the raptor-dependent component of mTOR-catalyzed p70S6k phosphorylation in vitro. tos eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens