Pub. Date : 2003 May 2
PMID : 12604597
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of the Ras-ERK pathway inhibits retinoic acid-induced stimulation of tissue transglutaminase expression in NIH3T3 cells. | Tretinoin | mitogen-activated protein kinase 1 | Mus musculus |
| 2 | Activation of the Ras-ERK pathway by EGF was sufficient to elicit this effect, since continuous Ras signaling mimicked the actions of EGF and inhibited RA-induced TGase expression, whereas blocking ERK activity in these same cells restored the ability of RA to up-regulate TGase expression. | Tretinoin | mitogen-activated protein kinase 1 | Mus musculus |
| 3 | Activation of the Ras-ERK pathway by EGF was sufficient to elicit this effect, since continuous Ras signaling mimicked the actions of EGF and inhibited RA-induced TGase expression, whereas blocking ERK activity in these same cells restored the ability of RA to up-regulate TGase expression. | Tretinoin | mitogen-activated protein kinase 1 | Mus musculus |
| 4 | These findings demonstrate that TGase may serve as a survival factor and RA-induced TGase expression requires the activation of PI3K but is antagonized by the Ras-ERK pathway. | Tretinoin | mitogen-activated protein kinase 1 | Mus musculus |