Pub. Date : 2003 Mar
PMID : 12603818
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Effect of experimenter-delivered and self-administered cocaine on extracellular beta-endorphin levels in the nucleus accumbens. | Cocaine | proopiomelanocortin | Homo sapiens |
| 2 | Using microdialysis, we studied the effect of cocaine on extracellular levels of beta-endorphin in the nucleus accumbens, a brain region involved in the reinforcing effects of psychostimulant drugs. | Cocaine | proopiomelanocortin | Homo sapiens |
| 3 | The effect of cocaine on beta-endorphin release in the nucleus accumbens was mimicked by a local perfusion of dopamine (5 microm) and was blocked by coadministration of SCH-23390 (10 microm). | Cocaine | proopiomelanocortin | Homo sapiens |
| 4 | We demonstrate an increase in beta-endorphin release in the nucleus accumbens following experimenter-delivered and self-administered cocaine mediated by the local dopaminergic system. | Cocaine | proopiomelanocortin | Homo sapiens |
| 5 | These findings suggest that activation of the beta-endorphin neurons within the arcuate nucleus-nucleus accumbens pathway may be important in the neurobiological mechanisms underlying the behavioral effects of cocaine. | Cocaine | proopiomelanocortin | Homo sapiens |