Title : Protease-activated receptor 2-mediated vasodilatation in humans in vivo: role of nitric oxide and prostanoids.

Pub. Date : 2003 Feb 25

PMID : 12600906






1 Functional Relationships(s)
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1 Activation of PAR-2 receptors in vivo dilated human blood vessels in a dose-dependent manner, and the effects were reduced by inhibition of both nitric oxide and prostanoid synthesis CONCLUSIONS: These findings demonstrate that serine protease activity can cause human vasodilation and provide a possible explanation of why serine protease activation in critical illness is associated with vascular dysfunction. Prostaglandins coagulation factor II, thrombin Homo sapiens