Title : Polyglutamine expansion induces a protein-damaging stress connecting heat shock protein 70 to the JNK pathway.

Pub. Date : 2003 May 9

PMID : 12598532






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Using cell and mouse models, we have shown that expanded polyglutamine led to activation of the stress kinase JNK and the transcription factor AP-1, which are implicated in neuronal death. polyglutamine jun proto-oncogene Mus musculus
2 We suggest that reduction of HSP70 by expanded polyglutamine is implicated in aggregation and inhibition of M3/6 and in activation of JNK and AP-1. polyglutamine jun proto-oncogene Mus musculus