Title : Effects of selective cyclooxygenase-2 inhibition on gingival tissue levels of prostaglandin E2 and prostaglandin F2alpha and clinical parameters of chronic periodontitis.

Pub. Date : 2003 Jan

PMID : 12593597






2 Functional Relationships(s)
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1 BACKGROUND: The purpose of the present study was to evaluate the effect of a relatively selective cyclooxygenase (COX)-2 inhibitor (nimesulide) and non-selective COX-1/COX-2 inhibitor (naproxen) used as an adjunct to non-surgical (scaling and root planing [SRP]) periodontal therapy in chronic periodontitis patients on the gingival tissue (GT) levels of prostaglandin (PG)E2 and PGF2alpha. nimesulide mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 CONCLUSIONS: Nimesulides, relatively selective COX-2 inhibitors, may have additional inhibitory effects on GT PGF2alpha levels in the first week following non-surgical periodontal treatment. nimesulide mitochondrially encoded cytochrome c oxidase II Homo sapiens