Pub. Date : 2003 Feb 20
PMID : 12592382
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a. | saikosaponin D | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | During this period, phosphorylation of one of the downstream transcriptional factors of MAPK cascade, ATF2, was 3.2- and 2.0-fold induced by TPA and Saikosaponin a, respectively, whereas that of another transcriptional factor, c-jun, was induced by TPA only. | saikosaponin D | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | Pretreatment of 20 microg/ml PD98059, an inhibitor of MEK which is the upstream kinase of ERK, prevents the TPA- and Saikosaponin a-triggered HepG2 growth inhibition by 50 and 30%, respectively, accompanied by a 50 - 85% decrease of the p15(INK4b)/p16(INK4a) RNAs and proteins induced by both drugs. | saikosaponin D | mitogen-activated protein kinase 1 | Homo sapiens |