Title : Kinetic and docking studies of the interaction of quinones with the quinone reductase active site.

Pub. Date : 2003 Feb 25

PMID : 12590585






1 Functional Relationships(s)
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1 The experimental and theoretical studies independently support a model in which quinones (with one to three fused aromatic rings) bind in the QR1 active site utilizing a pi-stacking interaction with the isoalloxazine ring of the FAD cofactor. Flavin-Adenine Dinucleotide NAD(P)H quinone dehydrogenase 1 Homo sapiens