Title : Mutations in autolytic loop-2 and at Asp554 of human prothrombin that enhance protein C activation by meizothrombin.

Pub. Date : 2003 Apr 25

PMID : 12588872






1 Functional Relationships(s)
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1 Strikingly, however, although meizothrombins modified by substitution of Asp(554) with either Ala or Leu or by deletion of loop-2 had 6-8 and <1%, respectively, of the clotting activity of alpha-thrombin, the activity of these meizothrombins for protein C was increased to >10 times that of alpha-thrombin. Leucine coagulation factor II, thrombin Homo sapiens