Title : Cyclosporin A prevents the hypoxic adaptation by activating hypoxia-inducible factor-1alpha Pro-564 hydroxylation.

Pub. Date : 2003 Apr 25

PMID : 12586829






1 Functional Relationships(s)
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1 We conclude that CsA destabilizes HIF-1alpha by promoting hydroxylation of Pro-564 in the ODD domain. Proline hypoxia inducible factor 1 subunit alpha Homo sapiens