Title : The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism.

Pub. Date : 2003 Apr

PMID : 12586735






2 Functional Relationships(s)
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1 Kv2.1 and Kv1.4 are highly expressed in beta-cells, and in Kv2.1-transfected tsA201 cells, 50 microM LY294002 and 100 microM LY303511 reversibly inhibited currents by 99% and 41%, respectively. LY 303511 potassium voltage-gated channel subfamily B member 1 Homo sapiens
2 Kv2.1 and Kv1.4 are highly expressed in beta-cells, and in Kv2.1-transfected tsA201 cells, 50 microM LY294002 and 100 microM LY303511 reversibly inhibited currents by 99% and 41%, respectively. LY 303511 potassium voltage-gated channel subfamily B member 1 Homo sapiens