Title : CYP1A1 and CYP1B1 in blood-brain interfaces: CYP1A1-dependent bioactivation of 7,12-dimethylbenz(a)anthracene in endothelial cells.

Pub. Date : 2003 Mar

PMID : 12584151






2 Functional Relationships(s)
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1 CYP1A1 and CYP1B1 in blood-brain interfaces: CYP1A1-dependent bioactivation of 7,12-dimethylbenz(a)anthracene in endothelial cells. anthracene cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus
2 Immunohistochemistry and autoradiography were used to identify sites of the cytochrome P450 enzymes (P450) 1A1 and 1B1 expression and activation of 7,12-dimethylbenz(a)anthracene (DMBA), in the brain of rodents pretreated with the aryl hydrocarbon receptor (AhR) agonists beta-naphthoflavone (BNF), 3,3",4,4",5-pentachlorobiphenyl or vehicle. anthracene cytochrome P450, family 1, subfamily b, polypeptide 1 Mus musculus