Pub. Date : 2003 Feb
PMID : 12581266
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | AIMS: To examine the predictive power of plasminogen activator inhibitor-1 (PAI-1) and the complexes it forms with tissue plasminogen activator (tPA-PAI-1) for the two major Type 1 diabetes (T1D) complications (coronary artery disease (CAD) and overt nephropathy) in the context of standard risk factors. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 2 | PAI-1 and tPA-PAI-1 were determined using ELISA methodology. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 3 | RESULTS: The 56 incident cases of CAD had marginally lower PAI-1 and higher tPA-PAI-1 levels compared with those free of CAD. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 4 | However, marginally higher PAI-1 and significantly higher tPA-PAI-1 (P = 0.04) levels were seen in those who developed nephropathy. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 5 | After controlling for age, both PAI-1 and tPA-PAI-1 showed significant negative correlations with HDL-cholesterol, and positive correlations with triglycerides, WHR, HbA1 and fibrinogen. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 6 | tPA-PAI-1 was also positively correlated with total and LDL-cholesterol. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |
| 7 | However, tPA-PAI-1 complexes may be involved in the pathogenesis of overt nephropathy. | Tetradecanoylphorbol Acetate | serpin family E member 1 | Homo sapiens |