Title : Differential effects of prostaglandin derived from omega-6 and omega-3 polyunsaturated fatty acids on COX-2 expression and IL-6 secretion.

Pub. Date : 2003 Feb 18

PMID : 12578976






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1 In this study, we compared the effects of PGE(2) and PGE(3) on (i) cell proliferation in NIH 3T3 fibroblasts, (ii) expression and transcriptional regulation of the COX-2 gene in NIH 3T3 fibroblasts, and (iii) the production of an inflammatory cytokine, IL-6, in RAW 264.7 macrophages. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 In this study, we compared the effects of PGE(2) and PGE(3) on (i) cell proliferation in NIH 3T3 fibroblasts, (ii) expression and transcriptional regulation of the COX-2 gene in NIH 3T3 fibroblasts, and (iii) the production of an inflammatory cytokine, IL-6, in RAW 264.7 macrophages. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
3 PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
4 PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
5 PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
6 PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
7 PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
8 PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
9 PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens
10 PGE(2) and PGE(3) both induce COX-2 mRNA via similar signaling mechanisms; however, compared with PGE(2), PGE(3) is significantly less efficient in inducing COX-2 gene expression. Prostaglandins E mitochondrially encoded cytochrome c oxidase II Homo sapiens