Title : Cytochrome P450 epoxygenases and vascular tone: novel role for HMG-CoA reductase inhibitors in the regulation of CYP 2C expression.

Pub. Date : 2003 Feb 17

PMID : 12573493






1 Functional Relationships(s)
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1 Cerivastatin and fluvastatin increase CYP 2C mRNA and protein in native and cultured endothelial cells, and enhance the bradykinin-induced NO/PGI(2)-independent relaxation of arterial segments as well as the generation of reactive oxygen species. Reactive Oxygen Species kininogen 1 Homo sapiens